Compounded NAD+ Face Cream

NAD+ injection works systemically — it raises circulating NAD+ across every tissue, including skin, but most of the dose is consumed by the liver, brain, muscle, and immune cells. The face cream is a strictly topical cosmetic that delivers NAD+ and small-molecule precursors directly into the upper layers of skin, where local keratinocytes and fibroblasts can use it. The two are complementary, not interchangeable: injection is a healthspan protocol, the cream is a skincare product with cosmetic claims only.

NAD+ itself is a relatively large, polar molecule, which is why most credible formulations also include smaller precursors like nicotinamide (vitamin B3), NMN, or NR that penetrate the stratum corneum more efficiently and convert to NAD+ inside cells. Independent skin-penetration data on topical NAD+ remains limited, which is why all marketing claims are cosmetic ("supports the appearance of...") rather than therapeutic.

Most patients notice a calmer, more hydrated feel within 1–2 weeks. Brightness and tone changes typically appear at 4–6 weeks, and texture or fine-line softening usually requires 8–12 weeks of consistent twice-daily use. Like all topical skincare, results depend on sun protection, sleep, and the rest of your routine.

Yes, but introduce slowly. In the first 2–4 weeks, alternate evenings — NAD+ cream one night, retinol the next — to assess tolerance. Vitamin C pairs well in the AM under SPF. If you stack actives, apply NAD+ cream after water-based serums and before heavier moisturizer or SPF.

It is generally well-tolerated, but sensitive or reactive skin should patch-test on the inner forearm for 48 hours before facial use, and start with PM-only application for the first two weeks. If you have active eczema, rosacea flares, or known reactivity to niacinamide or peptide creams, your prescribing doctor may recommend an alternative.

Not without dermatologist clearance. Most providers ask patients to wait until the barrier is fully re-epithelialized — typically 5–10 days after a chemical peel and 2–4 weeks after ablative laser — before reintroducing actives. Once cleared, gentle nightly application can support the recovery window.

A single airless pump bottle is formulated to last roughly 30 days at twice-daily, pea-sized application to the face, neck, and décolleté. Heavier application may shorten that window; spot use lengthens it. Keep the pump capped and stored away from heat and direct light to preserve the active.

Peptide12 partners with state-licensed compounding pharmacies that specialize in dermatologic preparations. Active ingredients are pharmaceutical-grade and every batch is tested for identity, potency, and microbial limits before release. Compounded NAD+ face cream is a cosmetic topical, not an FDA-approved drug, and is prepared from regulated active ingredients under individualized prescription.